PortaCellTec biosciences GmbH

PortaCellTec – the pathfinder for your drug

 

PortaCellTec (PCT) provides a broad spectrum of hepatic/renal uptake transporter assays (e.g. OATs, OCTs, OATPs) to investigate the inhibitor and substrate characteristics of your drug. As recommended by FDA and EMA we perform in vitro transporter studies with validated drug transporters stably-transfected in HEK-293 cells.


New! Quantification of non-labeled substrate uptake by LC-MS/MS




Efflux transporter assays


Gene name Protein name Probe substrates Probe inhibitors Transporter assays
ABCB1 MDR1 rhodamine123 verapamil,
cyclosporineA
efflux transporter assay
ABCG2 BCRP estrone-3- sulfate Ko143 vesicle-based
transporter assay
ABCB11 BSEP taurocholate cyclosporineA,
glibenclamide,
rifampicin
vesicle-based
transporter assay
ABCC2 MRP2 CDCF MK-571
benzbromarone
efflux transporter assay



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PortaCellTec Biosciences GmbH

 

Weender Landstraße 94 -108
37075 Göttingen
Tel : +49 551 309 66440
E-mail: PortaCellTec



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PortaCellTec

News

New validated products:

  • MATE1 and MATE2-K
  • OCTN2
  • PEPT1 and PEPT2
  • MDR1
  • BCRP
  • BSEP
  • MRP2

Events

German Pharm-Tox Summit 2016
Berlin, Germany
February 29 – March 3, 2016

AAPS-Workshop on Drug Transporters
Baltimore, USA
April 18 – 20, 2016

18th Barrier- and
Transporter-Meeting

Bad Herrenalb, Germany
May, 2016

Göttinger Transporttage 2016
Göttingen, Germany
October 15 – 16, 2016

 


Guidance for Industry (FDA and EMA)

Publications

 

 

PortaCellTec