Publications
➦ PortaCellTec Biosciences GmbH
- In Vitro Validation of an in Vivo Phenotyping Drug Cocktail for Major Drug Transporters in Humans. Hsin, C.-H.; Kuehne, A.; Gu, Y.; Jedlitschky, G.; Hagos, Y (2023). Gründemann, D.; Fuhr, U. Eur J Pharm Sci 2023, 186, 106459, doi:10.1016/j.ejps.2023.106459
- Investigations with Drugs and Pesticides Revealed New Species- and Substrate-Dependent Inhibition by Elacridar and Imazalil in Human and Mouse Organic Cation Transporter OCT2. Kuehne, A.; Floerl, S.; Hagos, Y (2022).. Int J Mol Sci 2022, 23, 15795, doi:10.3390/ijms232415795
- Functional Characterization and Comparison of Human and Mouse Organic Anion Transporter 1 as Drugs and Pesticides Uptake Carrier. Floerl S, Kuehne A, Hagos Y (2022). Eur J Pharm Sci 2022, 175, 106217, PMID: 35644507, DOI: 10.1016/j.ejps.2022.106217
- Functional and Pharmacological Comparison of Human and Mouse Na+/Taurocholate Cotransporting Polypeptide (NTCP). Floerl S, Kuehne A, Geyer J, Brockmoeller J, Tzvetkov MV, Hagos Y (2021). SLAS Discov. 26, 1055–1064, PMID: 34060352, DOI: 10.1177/24725552211017500
- Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction. Floerl S, Kuehne A, Hagos Y (2020). Int J Mol Sci 21, E6871, PMCID: PMC7559834 DOI: 10.3390/ijms21186871
- Interaction of the new monofunctional anticancer agent phenanthriplatin with transporters for organic cations. Hucke A, Park G, Bauer OB, Beyer G, Köppen C, Zeeh D, Wehe AC, Sperling M, Schröter R, Kantauskaitè M, Hagos Y, Karst U, Lippard SJ and Ciarimboli G (2018). Front Chem. 25; 6:180, 2018.
- Differential Interaction of Dantrolene, Glafenine, Nalidixic Acid, and Prazosin with Human Organic Anion Transporters 1 and 3. Burckhardt BC, Henjakovic M, Hagos Y, Burckhardt G. J Pharmacol Exp Ther. 2017 Sep;362(3):450-458. doi: 10.1124/jpet.117.241406. Epub 2017 Jun 19.PMID: 28630284
- Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3). Burckhardt BC, Henjakovic M, Hagos Y and Burckhardt G. Pflugers Arch 468: 1909-1918, 2016.
- Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron. Breljak D, Ljubojevic M, Hagos Y, Micek V, Balen ED, Vrhovac M, I, Brzica H, Karaica D, Radovic N, Kraus O, Anzai N, Koepsell H, Burckhardt G, Burckhardt BC and Sabolic I. Am J Physiol Renal Physiol 311: F227-F238, 2016.
- Beta-2 adrenergic-agonists are substrates and inhibitors of human organic cation transporter 1. Salomon, Johanna; Hagos, Yohannes; Petzke, Sören; Kühne, Annett; Gausterer, Julia; Hosoya, Ken-ichi; Ehrhardt, Carsten. Mol Pharm 12: 2633-2641, 2015.
- Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds. Marada VV, Flörl S, Kühne A, Burckhardt G, Hagos Y. Eur J Med Chem. 2015 Mar 6.
- Interaction of human organic anion transporter 2 (OAT2) and sodium taurocholate cotransporting polypeptide (NTCP) with antineoplastic drugs. Marada VV, Flörl S, Kühne A, Müller J, Burckhardt G, Hagos Y. Pharmacol Res. 2015 Jan.
- The Isoquinolone Derived Prolyl Hydroxylase Inhibitor ICA Is a Potent Substrate of the Organic Anion Transporters 1 and 3. Schulz K, Hagos Y, Burckhardt G, Schley G, Burzlaff N, Willam C, Burckhardt BC. Nephron. 2015;131(4):285-9. doi: 10.1159/000442531. Epub 2015 Dec 8.
- Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function. Henjakovic M, Hagos Y, Krick W, Burckhardt G, Burckhardt BC. Am J Physiol Renal Physiol. 2015 Nov 15;309(10):F843-51. doi: 10.1152/ajprenal.00140.2015. Epub 2015 Sep 16.
- Renal human organic anion transporter 3 increases the susceptibility of lymphoma cells to bendamustine uptake. Hagos Y, Hundertmark P, Shnitsar V, Marada VV, Wulf G, Burckhardt G. Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F330-8. doi: 10.1152/ajprenal.00467.2014. Epub 2014 Dec 4.
- The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes. Schnell C, Shahmoradi A, Wichert SP, Mayerl S, Hagos Y, Heuer H, Rossner MJ, Hülsmann S. Brain Struct Funct. 2015 Jan;220(1):193-203. doi: 10.1007/s00429-013-0645-0. Epub 2013 Oct 16.
- HNF4α induced chemosensitivity to oxaliplatin and 5-FU mediated by OCT1 and CNT3 in renal cell carcinoma. Hagos Y, Wegner W, Kuehne A, Floerl S, Marada VV, Burckhardt G, Henjakovic M J Pharm Sci. 2014 Oct.
- Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
Editors: Vogel, H.G., Maas, J., Hock, F.J., Mayer, D. (Eds.) 2nd ed. 2013; Springer-Verlag www.springer.com
Chapter 36; Distribution: Across Barriers by Tanja Eisenblaetter, Yohannes Hagos, Saskia Floerl, and Annett Kuehne ISBN 978-3-642-25239 - Human organic anion transporter OAT1 is not responsible for glutathione transport but mediates transport of glutamate derivatives. Hagos Y, Burckhardt G, Burckhardt BC. Am J Physiol Renal Physiol. 2013 Feb 15;304(4):F403-9. doi: 10.1152/ajprenal.00412.2012. Epub 2012 Dec 19. PMID: 23255614
- Active sulforhodamine 101 uptake into hippocampal astrocytes. Schnell C, Hagos Y, Hülsmann S. PLoS One. 2012;7(11):e49398. doi: 0.1371/journal.pone.0049398. Epub 2012 Nov 26.
