Drug Transporter Assays

PortaCellTec (PCT) offers a wide range of transporter assays. All transporters are stably overexpressed in HEK293 cells (human embryonic kidney cells) and each transporter is validated with the corresponding probe substrates and inhibitors.

➦ Important clinical relevant Transporters offered by PCT

TransporterGeneDrug EliminationProbe SubstratesProbe Inhibitors
OAT1 ▸SLC22A6renalp-Aminohippuric acidProbenecid, glibenclamide
OAT3 ▸SLC22A8renalEstrone-3-sulfateProbenecid, indomethacin
OATP1B1 ▸SLCO1B1hepaticEstrone-3-sulfateRifampicin, cyclosporine, ketoconazol
OATP1B3 ▸SLCO1B3hepaticSulfobromophthalein, cholecystokinin-8 (CCK-8)Rifampicin, cyclosporine, ketoconazol
OCT1 ▸SLC22A1hepaticMPP+, MetforminDecynium22, quinine, quinidine
OCT2 ▸SLC22A2renalMPP+, MetforminDecynium22, quinine, quinidine
MATE1 ▸SLC47A1hepatic/renalMPP+, MetforminCimetidine, quinidine, ketoconazol
MATE2K ▸SLC47A2renalMPP+, MetforminCimetidine, quinidine, ketoconazol
MDR1 ▸ABCB1hepatic/renalRhodamin123Cyclosporine, verapamil, LY335979
BCRP ▸ABCG2hepaticEstrone-3-sulfateKo143, elacridar, sulfosalazine
BSEP ▸ABCB11hepaticTaurocholateCyclosporine, glibenclamide, rifampicin

➦ All human Transporters offered by PCT

SLC Transporters
OCT1OATP1B1OAT1NTCP ▸MATE1 NaDC1 ▸PEPT1 ▸SERTOSTα/βLAT1NIS
OCT2OATP1B3OAT2 ▸ASBT ▸MATE2KNaDC3 ▸PEPT2 ▸LAT2
OCT3 ▸OATP1A2 ▸OAT3SOAT ▸
OCTN1OATP2A1OAT4 ▸
OCTN2 ▸OATP2B1 ▸
ABC Transporters
MDR1BCRPBSEPMRP2 ▸MRP3MRP4

➦ Transporters from other species offered by PCT

Rat (homologues gene)
roct1roat1rNisrOatp1b2
roct2 roat2
roct3roat3
Mouse (homologues gene)
moct1moat1mntcpmmate1mOatp1b2
moat3
moct2moat2mmdr1ammdr1b
moat6
GENERAL STRATEGY »