hOCTN2 (SLC22A5)
➦ Human OCTN2 (Organic Cation Transporter, Na+ /carnitine Cotransporter) has a relatively ubiquitous distribution and functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. Mutations in the SLC22A5 gene are the cause of systemic primary carnitine deficiency (SPCD), an autosomal recessive disorder.
| Main localization: | Kidney, small intestine, placenta, heart, liver |
| Transporter assay: | Uptake transporter assay (potential substrate and inhibitor) |
| Probe substrates: | L-carnitine |
| Probe inhibitors: | Verapamil, quinidine |
| Regulatory relevance: | − |
| Important interacting drugs: | Ipratropium, verapamil, quinidine, cefepime, cefoselis, cephaloridine, emetine, verapamil, quinidine |
➦ Concentration dependent inhibition of hOCTN2-mediated L-carnitine uptake by the probe inhibitor quinidine
