Drug Transporter Assays

PortaCellTec offers an extensive selection of transporter assays, in which each membrane transporter is stably overexpressed in HEK293 cells (human embryonic kidney cells) and validated using specific probe substrates and inhibitors.

➦ Important clinical relevant Transporters offered by PCT

TransportersGeneDrug EliminationProbe SubstratesProbe Inhibitors
OAT1 ▸SLC22A6renalp-Aminohippuric acidProbenecid, glibenclamide
OAT3 ▸SLC22A8renalEstrone-3-sulfateProbenecid, indomethacin
OATP1B1 ▸SLCO1B1hepaticEstrone-3-sulfateRifampicin, cyclosporine, ketoconazol
OATP1B3 ▸SLCO1B3hepaticSulfobromophthalein, cholecystokinin-8 (CCK-8)Rifampicin, cyclosporine, ketoconazol
OCT1 ▸SLC22A1hepaticMPP+, MetforminDecynium22, quinine, quinidine
OCT2 ▸SLC22A2renalMPP+, MetforminDecynium22, quinine, quinidine
MATE1 ▸SLC47A1hepatic/renalMPP+, MetforminCimetidine, quinidine, ketoconazol
MATE2K ▸SLC47A2renalMPP+, MetforminCimetidine, quinidine, ketoconazol
MDR1 ▸ABCB1hepatic/renalRhodamin123Cyclosporine, verapamil, LY335979
BCRP ▸ABCG2hepaticEstrone-3-sulfateKo143, elacridar, sulfosalazine
BSEP ▸ABCB11hepaticTaurocholateCyclosporine, glibenclamide, rifampicin

➦ All human Transporters offered by PCT

SLC Transporters
OCT1OATP1B1OAT1NTCP ▸MATE1 NaDC1 ▸PEPT1 ▸SERTOSTα/βLAT1NIS
OCT2OATP1B3OAT2 ▸ASBT ▸MATE2KNaDC3 ▸PEPT2 ▸LAT2
OCT3 ▸OATP1A2 ▸OAT3SOAT ▸
OCTN1OATP2A1OAT4 ▸
OCTN2 ▸OATP2B1 ▸
ABC Transporters
MDR1BCRPBSEPMRP2 ▸MRP3MRP4

➦ Transporters from other species offered by PCT

Rat (homologues gene)
roct1roat1rNisrOatp1b2
roct2 roat2
roct3roat3
roat6
Mouse (homologues gene)
moct1moat1mntcpmmate1mOatp1b2
moat3
moct2moat2mmdr1ammdr1b
moat6
GENERAL STRATEGY »